Pyrazolone is a ketone derivative of pyrazole having anti inflammatory, analgesic, antipyretic effect. Pyrazolone is a five-membered lactom ring compound contacting two nitrogen and ketone in the same molecule. Pyrazolones are well established in literature as important biologically active heterocyclic compounds. Pyrazolone in the class of nonsteroidal anti-inflammatory agents used in the treatment of arthritis and other musculoskeletal joint disorder. The objective of present study was, to synthesize the pyrazolone derivatives and to evaluate them for their anti-inflammatory activity. In the present work, a series of some pyrazolone derivatives (IIIa-g) and (IVa-g) were synthesized, characterized by TLC, melting point determination, IR, NMR and mass spectra and evaluated for their anti-inflammatory activity by in-vitro method using aspirin as a standard drug and antibacterial activity by using ciprofloxacin as a standard drug.
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